Fig. 1

Gut microbial enterotypes and bacterial co-abundance groups. A Clustering identified three microbial enterotypes in the Ath-HMDP mouse cohort. B Relative abundances of Firmicutes, Bacteroidetes, and Verrucomicrobia in the three enterotypes. C Correlation network of bacterial species (average relative abundance > 0.1% and present in at least 20% of samples) using CCREPE with a checkerboard score, indicating the co-occurrence or co-exclusion between species. Nodes represent the species and lines represent the similarity score. Solid lines represent co-occurrence bacterial species and dashed lines represent co-exclusion bacterial species. Significance was calculated by unpaired two-tailed Wilcoxon signed-rank test and is designated as follows: **p value < 0.01; ***p value < 0.001; ****p value < 0.0001. ET-B, Bacteroidetes enterotype; ET-F, Firmicutes enterotype; ET-V, Verrucomicrobia enterotype