Fig. 3

Construction of a four-bacterial signature in the training cohort. A–B Identification of differential bacterial genera between NPC and normal nasopharyngeal tissues (adjusted P value <0.05; |Fold Change|>2, left), as well as NPC tissues with or without relapse (adjusted P value <0.05; |Fold Change|>1.5, right) using the DESeq2. C Least absolute shrinkage and selection operator (LASSO) coefficient profiles of the candidate bacterial genera. D Ten-time cross-validations to tune the parameter selection in the LASSO model. The dotted vertical lines are drawn at the optimal values by minimum criteria